美国国立卫生研究院Rafael de Cabo团队近期取得重要工作进展。他们研究发现，将延长禁食时间与热量限制相结合可使成年雌性小鼠获得更大的衰老保护作用。相关研究成果于2023年7月11日在线发表于《细胞—代谢》杂志上。

据介绍，新出现的证据强调了延长每日禁食时间对雄性小鼠热量限制（CR）和限时喂养（TRF）的健康和生存益处的重要性，然而，这些喂养方案对雌性的影响目前还不清楚。

研究人员将14个月大的雌性小鼠置于五种不同的饮食方案中，即具有不同喂养窗口的CR或TRF，并确定这些方案对生理反应、肿瘤和炎症疾病的进展、血清代谢产物水平和寿命的影响。与TRF喂养相比，CR引发了强大的系统反应，因为它与能量学和健康跨度指标有关，这是过夜禁食动物的独特血清代谢组学特征，并与寿命的延长有关。

总之，这些结果表明，在生命后期开始的日间（休息阶段）喂养与延长禁食期与施加较低的能量摄入相结合会带来更大的益处。

附：英文原文

Title: Prolonged fasting times reap greater geroprotective effects when combined with caloric restriction in adult female mice

Author: Eleonora Duregon, Maria Emilia Fernandez, Jorge Martinez Romero, Clara Di Germanio, Meaghan Cabassa, Romaniya Voloshchuk, Margaux R. Ehrlich-Mora, Jacqueline M. Moats, Sarah Wong, Oye Bosompra, Annamaria Rudderow, Christopher H. Morrell, Simonetta Camandola, Nathan L. Price, Miguel A. Aon, Michel Bernier, Rafael de Cabo

Issue&Volume: 2023/07/11

Abstract: Emerging new evidence highlights the importance of prolonged daily fasting periodsfor the health and survival benefits of calorie restriction (CR) and time-restrictedfeeding (TRF) in male mice; however, little is known about the impact of these feedingregimens in females. We placed 14-month-old female mice on five different dietaryregimens, either CR or TRF with different feeding windows, and determined the effectsof these regimens on physiological responses, progression of neoplasms and inflammatorydiseases, serum metabolite levels, and lifespan. Compared with TRF feeding, CR eliciteda robust systemic response, as it relates to energetics and healthspan metrics, aunique serum metabolomics signature in overnight fasted animals, and was associatedwith an increase in lifespan. These results indicate that daytime (rest-phase) feedingwith prolonged fasting periods initiated late in life confer greater benefits whencombined with imposed lower energy intake.

DOI: 10.1016/j.cmet.2023.05.003

Source: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(23)00180-8