省级发布专栏
局部给药后眼药分布:家兔药代动力学模型
Final model: population parameters
Parameter |
Estimate |
% RSE |
[95 % CI] |
Mean prediction error (%); [95 %CI] |
---|---|---|---|---|
F1 |
0.300 |
6.65 |
[0.260; 0.340] |
21.7 [10.4; 33.1] |
k12 (h−1) nanosuspensions |
0.259 |
12.1 |
[0.197; 0.322] |
−25.0 [−29.6; −20.4] |
k12 (h−1) solution |
0.299 |
12.6 |
[0.224; 0.375] |
−25.0 [−29.6; −20.4] |
k13 (h−1) |
0.340 |
5.28 |
[0.304; 0.376] |
2.53 [−1.23; 6.29] |
Q (µL/h)a |
0.136 |
19.8 |
[0.0821; 0.190] |
32.2 [−2.45; 66.37] |
Clnl (µL/h)b |
275 |
9.87 |
[220; 329] |
20.5 [−17.7; 58.7] |
Clah (µL/h)c |
231 |
9.58 |
[187; 274] |
13.8 [5.09; 22.5] |
V1 (µL) |
155 |
16.4 |
[104; 206] |
39.7 [17.6; 61.9] |
V2 (µL) |
1.24 |
39.3 |
[0.266; 2.22] |
93.1 [−11.0; 196] |
V3 (µL) |
42.8 |
5.54 |
[38.1; 47.6] |
0.220 [−2.74; 3.18] |
V4 (µL) |
218 |
14.5 |
[155; 282] |
29.4 [2.98; 55.7] |
|
Estimate (%) |
CV % |
[95 % CI]—shrinkage % |
|
Inter-individual variability |
||||
F1 |
60.5 |
17.6 |
[48.7; 70.3]—1.97 |
|
k12 |
80.0 |
18.3 |
[63.8; 93.6]—91.5 |
|
k13 |
45.3 |
16.7 |
[37.0; 52.3]—59.7 |
|
Q |
172 |
17.3 |
[139; 199]—17.8 |
|
Clnl |
90.5 |
16.7 |
[73.9; 104]—19.2 |
|
Clah |
92.0 |
16.9 |
[74.9; 106]—74.4 |
|
V1 |
153 |
17.0 |
[124; 177]—47.4 |
|
V2 |
437 |
18.4 |
[347; 511]—60.6 |
|
V3 |
51.1 |
18.2 |
[40.8; 59.7]—98.5 |
|
V4 |
265 |
18.6 |
[210; 311]—81.8 |
|
Residual variability |
|
|||
σ |
0.491 |
107 |
[NA; 0.871]—99.8 |
|
编辑信箱
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