法国巴黎大学Benjamin Terrier等研究人员合作揭示COVID-19患者I型干扰素活性及炎症反应与疾病程度的相关性。2020年7月13日，《科学》杂志在线发表了这项成果。

 研究人员对50名患有各种疾病严重程度的COVID-19患者进行了综合免疫分析。在重症和重症患者中研究人员观察到独特的表型，包括高度受损的I型干扰素（IFN）反应（以无IFN-β和低的IFN-α产生和活性为特征），伴有持续的病毒载量以及加重疾病恶化的炎症反应。炎症部分由转录因子NF-κB驱动，其特征是肿瘤坏死因子（TNF）-α和白介素（IL）-6的产生和信号增加。

这些数据表明血液中的I型IFN缺乏可能是严重COVID-19的标志，并为联合治疗方法提供了依据。

据介绍，2019冠状病毒疾病（COVID-19）的特征在于疾病进展的不同模式，从而表明这其中存在多种宿主免疫反应。

附：英文原文

Title: Impaired type I interferon activity and inflammatory responses in 

severe COVID-19 patients

Author: Jérme Hadjadj, Nader Yatim, Laura Barnabei, Aurélien Corneau, 

Jeremy Boussier, Nikaa Smith, Hélène Péré, Bruno Charbit, Vincent 

Bondet, Camille Chenevier-Gobeaux, Paul Breillat, Nicolas Carlier, Rémy 

Gauzit, Caroline Morbieu, Frédéric Pène, Nathalie Marin, Nicolas Roche, 

Tali-Anne Szwebel, Sarah H Merkling, Jean-Marc Treluyer, David Veyer, 

Luc Mouthon, Catherine Blanc, Pierre-Louis Tharaux, Flore Rozenberg, 

Alain Fischer, Darragh Duffy, Frédéric Rieux-Laucat, Solen Kernéis, 

Benjamin Terrier

Issue&Volume: 2020/07/13

Abstract: Abstract Coronavirus disease 2019 (COVID-19) is characterized 

by distinct patterns of disease progression suggesting diverse host 

immune responses. We performed an integrated immune analysis on a 

cohort of 50 COVID-19 patients with various disease severity. A unique 

phenotype was observed in severe and critical patients, consisting of a 

highly impaired interferon (IFN) type I response (characterized by no IFN-

β and low IFN-α production and activity), associated with a persistent 

blood viral load and an exacerbated inflammatory response. 

Inflammation was partially driven by the transcriptional factor NF-κB and 

characterized by increased tumor necrosis factor (TNF)-α and interleukin 

(IL)-6 production and signaling. These data suggest that type-I IFN 

deficiency in the blood could be a hallmark of severe COVID-19 and 

provide a rationale for combined therapeutic approaches.

DOI: 10.1126/science.abc6027

Source: https://science.sciencemag.org/content/early/2020/07/10/science.abc6027

期刊信息

Science：《科学》，创刊于1880年。隶属于美国科学促进会，最新IF：41.037

官方网址：https://www.sciencemag.org/

投稿链接：https://cts.sciencemag.org/scc/#/login