美国密歇根大学S. D. Pletcher小组发现，饥饿对神经元组蛋白修饰的影响减缓果蝇的衰老速度。2023年5月12日，国际知名学术期刊《科学》发表了这一成果。

研究人员发现饥饿感能调节果蝇的衰老。限制支链氨基酸（BCAA）或激活饥饿促进神经元诱发饥饿状态，尽管喂养量增加，但寿命延长。神经元组蛋白乙酰化组的改变与BCAA的限制有关，防止这些改变可消除BCAA限制对增加进食和延长寿命的影响。饥饿通过使用组蛋白变体H3.3急性增加进食，而长期饥饿似乎减少了饥饿设定点，导致对衰老的有利影响。饥饿感对延长寿命的充分性的证明，揭示了动机状态本身可以成为衰老的决定性驱动因素。

据介绍，饥饿是一种古老的驱动力，然而这类压力的分子性质以及它们如何调节生理学都是未知的。

附：英文原文

Title: Effects of hunger on neuronal histone modifications slow aging in Drosophila

Author: K. J. Weaver, R. A. Holt, E. Henry, Y. Lyu, S. D. Pletcher

Issue&Volume: 2023-05-12

Abstract: Hunger is an ancient drive, yet the molecular nature of pressures of this sort and how they modulate physiology are unknown. We find that hunger modulates aging in Drosophila. Limitation of branched-chain amino acids (BCAAs) or activation of hunger-promoting neurons induced a hunger state that extended life span despite increased feeding. Alteration of the neuronal histone acetylome was associated with BCAA limitation, and preventing these alterations abrogated the effect of BCAA limitation to increase feeding and extend life span. Hunger acutely increased feeding through usage of the histone variant H3.3, whereas prolonged hunger seemed to decrease a hunger set point, resulting in beneficial consequences for aging. Demonstration of the sufficiency of hunger to extend life span reveals that motivational states alone can be deterministic drivers of aging.

DOI: ade1662

Source: https://www.science.org/doi/10.1126/science.ade1662