2013年8月1日 生物谷讯/ --近日英国科学家表示他们利用组织在小鼠身上培养出接近成人耳朵类似物的组织。这个类似物的功能和形态都与成人耳朵很接近。

    此前工作人员培养出了婴儿耳朵类似物，此次的成果将是人类距培养出一个具有完整功能的人耳的梦想更进一步。

     近年来，组织培养分化人类器官已经成为医药领域中一个热点。（生物谷Bioon.com）

详细英文报道：

US scientists say they have moved a step closer to being able to grow a complete human ear from a patient's cells.

In a new development in tissue engineering, they have grown a human-like ear from animal tissue.

The ear has the flexibility of a real ear, say researchers at Massachusetts General Hospital in Boston.

The technique may one day be used to help people with missing or deformed outer ears, they believe.

Tissue engineering is a growing field in medical science, where substitute organs are made in the laboratory in the hope of using them to replace damaged ones.

The US research team is working on artificial living ears to help people born with malformed ears or who have lost them in accidents or trauma.

Previously the researchers had grown an artificial ear, the size of a baby's, on a mouse.

In the latest development, published in the Journal of the Royal Society Interface, they took living tissues from cows and sheep and grew them on a flexible wire frame that has the 3D shape of a real human ear.

This was then implanted into a rat whose immune system they had suppressed enabling the ear to grow.

"We've demonstrated the first full-sized adult human ear on the rat model," Dr Thomas Cervantes, who led the study, told BBC News.

It was significant for several reasons, he said.

"One - we were able to keep the shape of the ear, after 12 weeks of growth in the rat. And then secondly we were also able to keep the natural flexibility of the cartilage."

Titanium scaffold

The cells were grown on a titanium wire scaffold that is modelled on the dimensions of a real human ear, taken from CT scans.

The new work shows that in theory it is possible to grow up enough cells - at least in animals - to make a full-size human ear.

"In a clinical model, what we would do is harvest a small sample of cartilage, that the patient has, and then expand that so we could go ahead and do the same process," said Dr Cervantes.

"This research is a significant step forward in preparing the tissue-engineered ear for human clinical trials."

He said he expected that the process could move into human clinical trials in about five years.